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Go to Section. Home Organization Science Vol. Kathleen M. Nathan R. Christopher B. Previous Back to Top. Figures References Related Information Cited By Affective organizational commitment in global strategic partnerships: The role of individual-level microfoundations and social change.
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What Facilitates Dynamic Capabilities? The Role of Organizational Climate for Trust. Neurol Med Chir Tokyo 4 : — Sano K Mayanagi Y : Posteromedial hypothalamotomy in the treatment of violent, aggressive behaviour. J Neurosurg 33 : — London : Academic Press pp — Curr Biol 24 : R — R Sapru HN : Role of the hypothalamic arcuate nucleus in cardiovascular regulation. Auton Neurosci : 38 — 50 Schmidt G Schorsch E : Psychosurgery of sexually deviant patients: review and analysis of new empirical findings. Arch Sex Behav 10 : — Brain : — J Neurol Neurosurg Psychiatry 35 : — J Clin Invest 98 : — Neuropharmacology 26 : — Behav Brain Res : — Sternson SM : Hypothalamic survival circuits: blueprints for purposive behaviors.
Neuron 77 : — Nat Neurosci 19 : — An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker. Swayze VW II : Frontal leukotomy and related psychosurgical procedures in the era before antipsychotics — : a historical overview. Am J Psychiatry : — Am J Physiol : R — R Front Syst Neurosci 6 : 51 Int J Obes 36 : — Nat Rev Neurosci 10 : — Department of Health Education, and Welfare: Protection of human subjects. Use of psychosurgery in practice and research: report and recommendations of National Commission for the Protection of Human Subjects.
Fed Regist 42 : — New York : Basic Books Psychiatry Res 34 : 1 — 11 Vann SD : Re-evaluating the role of the mammillary bodies in memory. Neuropsychologia 48 : — J Nerv Ment Dis 71 : — Wheatley MD : The hypothalamus and affective behavior in cats: a study of the effects of experimental lesions, with anatomic correlations.
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Arch Neurol Psychiatry 52 : — J Neurosurg : 56 — 63 Cell : — Nutr Metab Lond 11 : 27 Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. Functional Organization of the Hypothalamus The human hypothalamus is a small anatomically heterogeneous brain region involved in a gamut of physiological processes ranging from vegetative and endocrine functions to higher-order social behavior.
TABLE 1. The Nuclear Zone In contrast to the PVZ, the nuclear and lateral zones are larger relative to overall brain volume and more complex in humans compared with other mammals. The Lateral Zone The lateral hypothalamus represents the associative zone of the hypothalamus; a number of complex fiber systems make their way through this zone toward and from the hypothalamic nuclei in relation to distant regions of the forebrain and brainstem.
The Hypothalamus as a Stereotactic Target Lessons From the Past: The Hypothalamotomies Four groups published the main papers on the hypothalamus as a psychosurgical target to treat refractory aggressive behavior. Behavioral Effects of Hypothalamic Stimulation in the DBS Era The development of DBS and modern stereotactic techniques has allowed the resurgence of the hypothalamus as a target for ethically accepted psychosurgical interventions.
TABLE 2. TABLE 3. Implications for the Future The hypothalamus has been used as a stereotactic target throughout the decades of the neurosurgical endeavor to ameliorate the mind and behavior in a host of otherwise hopeless psychiatric disorders. Summary and Conclusions Interest in the hypothalamus as a potential target for psychosurgery dates back to the beginning of the 20th century.
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Fed Regist 42 : — , false. New York : Basic Books , false. Psychiatry Res 34 : 1 — 11 , Neuropsychologia 48 : — , J Nerv Ment Dis 71 : — , Arch Neurol Psychiatry 52 : — Crossref Wheatley MD : The hypothalamus and affective behavior in cats: a study of the effects of experimental lesions, with anatomic correlations.
Arch Neurol Psychiatry 52 : — , J Neurosurg : 56 — 63 , Cell : — , Nutr Metab Lond 11 : 27 , Article Information. Keywords: hypothalamus ; deep brain stimulation ; mental disorders ; psychosurgery Page Count: E View in gallery A and C: Schematic drawings of hypothalamic nuclei, lateral view from the midline, showing the nuclei directly located under the wall of the third ventricle A and the more deeply located nuclei up to the lateral region C.
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View raw image Close. Preoptic or chiasmal. Thermal regulation, endocrine regulation of sexual behavior. Regulation of circadian rhythms. Secretion of neurohypophyseal hormones. Tuberal or infundibular. Food intake, cardiovascular regulation, monitoring of adipose tissue fat. Episodic memory encoding. Hamani et al. Case report. Ventral hypothalamus bilat. Refractory morbid obesity. Hernando et al. PMH bilat. Kuhn et al. Refractory self-aggressive behavior after brain injury. Subjective experience of inner peace, disappearance of self-aggressive behavior.
Franzini et al. Case series. Torres et al. Refractory aggressive behavior related to mental retardation. Whiting et al. Pilot study. LHA bilat. Decreased urge to eat, increased energy levels. Micieli et al. Lat part of lt PM hypothalamus. Induction of aggressive behavior. VPH ipsilat. Schoenen et al. Induction of panic attacks in 1 pt. Rasche et al. Induction of panic attacks. Bartsch et al. Case series multicenter. Induction of panic attacks in 2 pts.
Evocation of detailed autobiographical memories. Wilent et al.