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Go to Section. Home Organization Science Vol. Kathleen M. Nathan R. Christopher B. Previous Back to Top. Figures References Related Information Cited By Affective organizational commitment in global strategic partnerships: The role of individual-level microfoundations and social change.

Ambidextrous capacity in small and medium-sized enterprises. Safety as strategy: Mistakes, failures and fiascos in high-risk systems. How organizations implement new practices in dynamic context: role of deliberate learning and dynamic capabilities development in health care units. When less is more: the downside of customer knowledge sharing in new product development teams. Supply chain and logistics competencies in humanitarian aid. The microfoundations of an operational capability in digital manufacturing. Six Sigma for dynamic capabilities development: becoming more flexible organizations.

The Importance of Strategic Fit. On the future of international joint venture research. Capability creation: Heuristics as microfoundations. Information technology outsourcing and architecture dynamic capabilities as enablers of organizational agility. Entrepreneurial team and strategic agility: A conceptual framework and research agenda.


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What, when, and who: Manager involvement in predicting employee resistance to acquisition integration. Behind ambidextrous search: The microfoundations of search in family and non-family firms. Fernando F. Suarez , Juan S. Sunkee Lee. System Dynamics Review and publications — analysis, synthesis and contributions. The influence of collaboration-oriented organisational capabilities on supply chain competence among small and medium enterprises. Multicultural managers and competitive advantage: Evidence from elite football teams.

Does Korean-style management have a future? Managing formalization to increase global team effectiveness and meaningfulness of work in multinational organizations. Flamingos on a slackline: Companies' challenges of balancing the competing demands of handling customer information and privacy. Doing complexity leadership theory: How agile coaches at Spotify practise enabling leadership. A Multilevel Framework of Alliance Management. Introducing conflict as the microfoundation of organizational ambidexterity.

Microfoundations of companies' dynamic capabilities for environmentally sustainable innovation: Case study insights from high-tech innovation in science-based companies. How does de-globalization affect location decisions? A study of managerial perceptions of risk and return. Antecedents, mediators and consequences of sustainable operations.

Micro-foundations of innovation. The goblet and two faces. The weight of organizational factors on heuristics. On micro-foundations of dynamic capabilities: A multi-level perspective based on CEO personality and knowledge-based capital. Resilience as an entrepreneurial capability: integrating insights from a cross-disciplinary comparison. Demand variation, strategic flexibility and market entry: Evidence from the U.

Looking different vs thinking differently: Impact of TMT diversity on coopetition capability. Managing the exploration-exploitation paradox in healthcare. Managing the tensions between exploration and exploitation: The role of time. Effects of high-performance work systems on transformational leadership and team performance: Investigating the moderating roles of organizational orientations. The multiple faces of tension: dualities in decision-making. Risk management and firm performance: the moderating role of supplier integration. The merits of playing it by the book: routine versus deliberate learning and the development of dynamic capabilities.

On the relationship between creativity and standardisation: evidence from a qualitative study on the introduction of standardised evaluation framework in recruitment. The sources of dynamism in dynamic capabilities. Capability configuration, ambidexterity and performance: Evidence from service outsourcing sector. Balanced scorecard in SMEs: effects on innovation and financial performance. Environmental shifts and change strategies. Chaos in Industry Environments. Design thinking is ambidextrous. Reconciling digital transformation and knowledge protection: a research agenda.

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Project capabilities for operational outcomes in inter-organisational settings: The case of London Heathrow Terminal 2. The organizational environment with its measures, antecedents, and consequences: a review and research agenda. A joint analysis of determinants and performance consequences of ambidexterity. Supply chain flexibility in dynamic environments. How to solve the dilemma of balancing between efficiency and flexibility in project-oriented organizations. Entrepreneurial initiatives as a microfoundation of dynamic capabilities. Developing Individual Competencies for Humanitarian Logistics.

Attention and Entrepreneurial Cognition. Cognitive Variety in Rich-Challenging Tasks. Meta-synthesis management framework of a complex project: A case study of the deck pavement project of the Hong Kong-Zhuhai-Macao Bridge. Quo Vadis, Dynamic Capabilities? Revue internationale P. Seeing through the network: Competitive advantage in the digital economy. Managerial attention to exploitation versus exploration: toward a dynamic perspective on ambidexterity. Embedding real options in scenario planning: A new methodological approach. Dynamic capabilities and firm performance.

What Facilitates Dynamic Capabilities? The Role of Organizational Climate for Trust. Neurol Med Chir Tokyo 4 : — Sano K Mayanagi Y : Posteromedial hypothalamotomy in the treatment of violent, aggressive behaviour. J Neurosurg 33 : — London : Academic Press pp — Curr Biol 24 : R — R Sapru HN : Role of the hypothalamic arcuate nucleus in cardiovascular regulation. Auton Neurosci : 38 — 50 Schmidt G Schorsch E : Psychosurgery of sexually deviant patients: review and analysis of new empirical findings. Arch Sex Behav 10 : — Brain : — J Neurol Neurosurg Psychiatry 35 : — J Clin Invest 98 : — Neuropharmacology 26 : — Behav Brain Res : — Sternson SM : Hypothalamic survival circuits: blueprints for purposive behaviors.

Neuron 77 : — Nat Neurosci 19 : — An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker. Swayze VW II : Frontal leukotomy and related psychosurgical procedures in the era before antipsychotics — : a historical overview. Am J Psychiatry : — Am J Physiol : R — R Front Syst Neurosci 6 : 51 Int J Obes 36 : — Nat Rev Neurosci 10 : — Department of Health Education, and Welfare: Protection of human subjects. Use of psychosurgery in practice and research: report and recommendations of National Commission for the Protection of Human Subjects.

Fed Regist 42 : — New York : Basic Books Psychiatry Res 34 : 1 — 11 Vann SD : Re-evaluating the role of the mammillary bodies in memory. Neuropsychologia 48 : — J Nerv Ment Dis 71 : — Wheatley MD : The hypothalamus and affective behavior in cats: a study of the effects of experimental lesions, with anatomic correlations.

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Arch Neurol Psychiatry 52 : — J Neurosurg : 56 — 63 Cell : — Nutr Metab Lond 11 : 27 Disclosures The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. Functional Organization of the Hypothalamus The human hypothalamus is a small anatomically heterogeneous brain region involved in a gamut of physiological processes ranging from vegetative and endocrine functions to higher-order social behavior.

TABLE 1. The Nuclear Zone In contrast to the PVZ, the nuclear and lateral zones are larger relative to overall brain volume and more complex in humans compared with other mammals. The Lateral Zone The lateral hypothalamus represents the associative zone of the hypothalamus; a number of complex fiber systems make their way through this zone toward and from the hypothalamic nuclei in relation to distant regions of the forebrain and brainstem.

The Hypothalamus as a Stereotactic Target Lessons From the Past: The Hypothalamotomies Four groups published the main papers on the hypothalamus as a psychosurgical target to treat refractory aggressive behavior. Behavioral Effects of Hypothalamic Stimulation in the DBS Era The development of DBS and modern stereotactic techniques has allowed the resurgence of the hypothalamus as a target for ethically accepted psychosurgical interventions.

TABLE 2. TABLE 3. Implications for the Future The hypothalamus has been used as a stereotactic target throughout the decades of the neurosurgical endeavor to ameliorate the mind and behavior in a host of otherwise hopeless psychiatric disorders. Summary and Conclusions Interest in the hypothalamus as a potential target for psychosurgery dates back to the beginning of the 20th century.

Nature : , Neurosurgery 44 : — , Yale J Biol Med 24 : — , false. Biol Psychiatry 71 : — , Acta Neurochir Suppl 21 : — , false. Confin Neurol 37 : — , Eur J Neurosci 37 : — , Cephalalgia 28 : — , J Hist Neurosci 22 : 14 — 29 , Neurology 59 : — , Berlin : Springer , , pp — Horm Behav 54 : — , Neurosci Biobehav Rev 35 : — , J Hist Neurosci 23 : — , PLoS One 11 : e , Lancet : — Crossref Cushing H : Neurohypophyseal mechanisms from a clinical standpoint.

Lancet : — , New York : Springer , , pp — false. Am J Physiol : — , Appl Neurophysiol 41 : 93 — 98 , false. Acta Neurochir Suppl Wien 44 : — , false. Neurosurg Focus 38 6 : E7 , FOCUS false. J Neuroendocrinol 25 : 48 — 55 Crossref Ebner K , Muigg P , Singewald N : Inhibitory function of the dorsomedial hypothalamic nucleus on the hypothalamic-pituitary-adrenal axis response to an emotional stressor but not immune challenge.

J Neuroendocrinol 25 : 48 — 55 , Neurosurgery 52 : — PubMed Franzini A , Ferroli P , Leone M , Broggi G : Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 52 : — , false. Stereotact Funct Neurosurg 83 : 63 — 66 , Acta Neurochir Suppl 97 : — , Neurosurg Focus 29 2 : E13 , Berlin : Reimer , Ger false.

J Psychiatry Neurosci 40 : — , Nat Neurosci 9 : — , J Endocrinol 25 : — , Ann Neurol 63 : — , Compr Physiol 6 : — , Stereotact Funct Neurosurg 86 : — , Neuro Endocrinol Lett 29 Suppl 1 : 7 — 68 , false. Leipzig : Barth Ger Kleist K : [War injuries of the brain and their implications for neuroanatomy and neuropathology. Leipzig : Barth , Ger false.

J Comp Neurol : — , Gesnerus 62 : 77 — , false. Neurosurgery 62 : E , J Neurosurg : — , Acta Neurochir Wien 75 : 5 — 22 , J Anat 70 : — , 3 , false. Nature : — , New York : Springer , , pp 1 — 20 false. Brain Res : 43 — 64 , Am J Drug Alcohol Abuse 35 : — , Neurosurg Focus 25 1 : E9 , Ann Neurol 66 : — , PLoS One 7 : e , Trans Am Neurol Assoc 86 : 81 — 85 PubMed Meyers R : Evidence of a locus of the neural mechanisms for libido and penile potency in the septo-fornico-hypothalamic region of the human brain.

Trans Am Neurol Assoc 86 : 81 — 85 , false. J Neurosurg 19 : 71 — 81 Crossref PubMed Meyers R : Three cases of myoclonus alleviated by bilateral ansotomy, with a note on postoperative alibido and impotence. J Neurosurg 19 : 71 — 81 , JNS false. Mol Cell Endocrinol : 79 — 88 , Am J Psychiatry 93 : — , Stud Health Technol Inform : — , false. Neurochirurgia Stuttg 16 : — , false. Science : — , Neural Plast : , false. J Neurophysiol 9 : — , New York : Elsevier , , pp — false. J Neurosci 29 : — , Lancet 1 : , Letter Acta Neurochir Wien 30 : — , Arch Sex Behav 8 : — , Confin Neurol 27 : — , Springfield : Charles C Thomas , , pp 87 — false.

New York : Oxford University Press , , pp — false. Neurosurgery 59 : — , Neurol Med Chir Tokyo 4 : — Crossref Sano K : Sedative neurosurgery with special reference to posteromedial hypothalamotomy. Neurol Med Chir Tokyo 4 : — , J Neurosurg 33 : — , London : Academic Press , , pp — false.

Curr Biol 24 : R — R , false. Auton Neurosci : 38 — 50 , Arch Sex Behav 10 : — , Brain : — , J Neurol Neurosurg Psychiatry 35 : — , J Clin Invest 98 : — , Neuropharmacology 26 : — , Behav Brain Res : — , Neuron 77 : — , Nat Neurosci 19 : — , Am J Psychiatry : — , Am J Physiol : R — R , false. Front Syst Neurosci 6 : 51 , Int J Obes 36 : — , Nat Rev Neurosci 10 : — , Fed Regist 42 : — PubMed U. Department of Health , Education, and Welfare: Protection of human subjects.

Fed Regist 42 : — , false. New York : Basic Books , false. Psychiatry Res 34 : 1 — 11 , Neuropsychologia 48 : — , J Nerv Ment Dis 71 : — , Arch Neurol Psychiatry 52 : — Crossref Wheatley MD : The hypothalamus and affective behavior in cats: a study of the effects of experimental lesions, with anatomic correlations.

Arch Neurol Psychiatry 52 : — , J Neurosurg : 56 — 63 , Cell : — , Nutr Metab Lond 11 : 27 , Article Information. Keywords: hypothalamus ; deep brain stimulation ; mental disorders ; psychosurgery Page Count: E View in gallery A and C: Schematic drawings of hypothalamic nuclei, lateral view from the midline, showing the nuclei directly located under the wall of the third ventricle A and the more deeply located nuclei up to the lateral region C.

D.Gray-man, Vol. 7

View raw image Close. Preoptic or chiasmal. Thermal regulation, endocrine regulation of sexual behavior. Regulation of circadian rhythms. Secretion of neurohypophyseal hormones. Tuberal or infundibular. Food intake, cardiovascular regulation, monitoring of adipose tissue fat. Episodic memory encoding. Hamani et al. Case report. Ventral hypothalamus bilat. Refractory morbid obesity. Hernando et al. PMH bilat. Kuhn et al. Refractory self-aggressive behavior after brain injury. Subjective experience of inner peace, disappearance of self-aggressive behavior.

Franzini et al. Case series. Torres et al. Refractory aggressive behavior related to mental retardation. Whiting et al. Pilot study. LHA bilat. Decreased urge to eat, increased energy levels. Micieli et al. Lat part of lt PM hypothalamus. Induction of aggressive behavior. VPH ipsilat. Schoenen et al. Induction of panic attacks in 1 pt. Rasche et al. Induction of panic attacks. Bartsch et al. Case series multicenter. Induction of panic attacks in 2 pts.

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Evocation of detailed autobiographical memories. Wilent et al.